In the controlled human malaria infection model, the disease is triggered in a controlled manner to test therapies and vaccines.
Detailed description
The malaria pathogens used for immunization meet the criteria for drug approval. The model was developed at the Institute of Tropical Medicine of the University of Tübingen, which belongs to the DZIF.
More about “Controlled human malaria infection model”
While our understanding of the immune response to malaria improves, an efficient malaria vaccine remains elusive. We intend to use blood stage attenuated parasites which can be transmitted through mosquitoes as tools to dissect human responses to malaria parasites and as a novel vaccination strategy ...
Each year, over 200 million people worldwide contract malaria. The malaria pathogens, called plasmodia, are transmitted by mosquitoes and pass through different stages of development in the liver and red blood cells. Humans develop immunity against the disease after having been routinely exposed to ...
The Clinical Trials Platform at the Tübingen Institute of Tropical Medicine supports the development of new agents and vaccines against infectious diseases. It focuses on conducting experimental studies and first trials on humans. A special feature is the human malaria infection model, developed in ...
Scientists at the Institute of Tropical Medicine of the University of Tübingen, the German Center for Infection Research (DZIF), and of Sanaria Inc. have developed an infection system that allows
