Corallopyronin A | German Center for Infection Research

Short description

Corallopyronin A is a natural compound antibiotic. It is effective against Gram-positive bacteria and intracellular Gram-negative bacteria.

Detailed description

Corallopyronin A was isolated from environmental bacteria. It targets the bacterial enzyme RNA polymerase. It is effective against Gram-positive bacteria and intracellular Gram-negative bacteria: Wolbachia, Chlamydia spp., Rickettsia spp. and Orientia tsutsugamushi.

Banner der WHO zur World AMR Awareness Week 2024

World AMR Awareness Week 2024, 18-24 November – Educate. Advocate. Act now.

Antimicrobial resistance (AMR) is one of the most urgent challenges facing global health and development. Described as a “creeping pandemic” by the G7 forum of leading economic nations, AMR occurs

Apr 2024

Microbiol Spectr

A laboratory-based predictive pathway for the development of Neisseria gonorrhoeae high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase

Autoren

Balthazar JT et al.

Prof Achim Hoerauf in his laboratory at the University Hospital Bonn

New antibiotic against river blindness and lymphatic filariasis pathogens

A team led by Prof Achim Hoerauf in the German Center for Infection Research (DZIF) is further developing the antibiotic corallopyronin A as a treatment for the neglected tropical diseases river

30 January—World Neglected Tropical Diseases Day

The World Neglected Tropical Diseases Day on 30 January under the motto UNITE.ACT.ELIMINATE draws attention to neglected tropical diseases (NTDs) and the suffering they cause. More than one billion

World AMR Awareness Week from 18 to 24 November: Preventing antimicrobial resistance together

From 18 to 24 November, the “World AMR Awareness Week” (WAAW), a global campaign proclaimed by WHO, aims to draw attention to the near-pandemic rise in infections caused by resistant microbial

Several silver-coloured bioreactors with many connecting tubes and control screens used for fermentation and production of active agents.

Clinical development of two antimicrobial agents funded by Else Kröner-Fresenius Foundation

The Else Kröner-Fresenius Foundation's ForTra gGmbH for Research Transfer—the largest medicine-funding foundation in Germany—supports the legally compliant production of new drug candidates for direct

Dec 2022

Pharmaceutics

Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus

Autoren

Rox K et al.

30 January – World Neglected Tropical Diseases Day

More than one billion people worldwide are at risk of illness, disfigurement, disability, and even death from neglected tropical diseases (NTDs). Especially in the poorest regions of the world where

Sep 2022

Front Trop Dis

Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes

Autoren

Ehrens A et al.

Sep 2022

mSphere

Potent In Vitro and Ex Vivo Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A

Autoren

Edwards JL et al.