Granuloma Breadcrumb Home Glossary Granuloma Short description A granuloma is a knot-shaped formation of new tissue. Detailed description The formation of a granuloma is often a reaction to infectious or allergic processes. In most cases, granulomas are benign. More about “Granuloma” © CC BY 4.0/Images modified from: Römpp, A., Treu, A., Kokesch-Himmelreich, J. et al. The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis. Nat Commun 16, 826 (2025). https://doi.org/10.1038/s41467-025-56146-9. Feb 17 2025 Novel antibiotic BTZ-043 also reaches tuberculosis bacteria hiding in dead lung tissue Every year, 10 million people contract tuberculosis (TB), a disease caused by the bacterium Mycobacterium tuberculosis (Mtb), and approximately 1.5 million patients succumb to the disease. Treatment Dec 2022 J Allergy Clin Immunol The efficacy and safety of systemic corticosteroids as first line treatment for granulomatous lymphocytic interstitial lung disease Autoren Smits B et al. Mar 2023 Antimicrob Agents Chemother Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model Autoren Eckhardt E et al. Mar 2022 Anal Chem Do Anti-tuberculosis Drugs Reach Their Target?─High-Resolution Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Provides Information on Drug Penetration into Necrotic Granulomas Autoren Kokesch-Himmelreich J et al. Dec 2021 Antimicrob Agents Ch Interleukin-13-Overexpressing Mice Represent an Advanced Preclinical Model for Detecting the Distribution of Antimycobacterial Drugs within Centrally Necrotizing Granulomas Autoren Walter K et al. Sep 2018 Clin Case Rep Postoperative granulomatous peritonitis mimicking abdominal tuberculosis Autoren Kasper P et al.
Dec 2022 J Allergy Clin Immunol The efficacy and safety of systemic corticosteroids as first line treatment for granulomatous lymphocytic interstitial lung disease Autoren Smits B et al.
Mar 2023 Antimicrob Agents Chemother Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model Autoren Eckhardt E et al.
Mar 2022 Anal Chem Do Anti-tuberculosis Drugs Reach Their Target?─High-Resolution Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Provides Information on Drug Penetration into Necrotic Granulomas Autoren Kokesch-Himmelreich J et al.
Dec 2021 Antimicrob Agents Ch Interleukin-13-Overexpressing Mice Represent an Advanced Preclinical Model for Detecting the Distribution of Antimycobacterial Drugs within Centrally Necrotizing Granulomas Autoren Walter K et al.
Sep 2018 Clin Case Rep Postoperative granulomatous peritonitis mimicking abdominal tuberculosis Autoren Kasper P et al.
