Hepatitis | German Center for Infection Research

Short description

Hepatitis is an infection of the liver, which, in most cases, is caused by hepatitis viruses.

Detailed description

There are five types of hepatitis viruses (A, B, C, D and E). Acute viral hepatitis is common in Germany. It is caused by hepatitis viruses A to E. Infections with hepatitis viruses B, C and D can take a chronic course and result in liver cirrhosis. Symptoms are first flu-like; in later phases of the disease a yellowing of the skin is often observed. Hepatitis may also be caused by certain autoimmune diseases or toxins. Acute hepatitis can proceed asymptomatically or manifest itself in yellowing of the skin and the eyes, nausea and an extreme fatigue. Hepatitis may lead to liver cirrhosis and liver cancer. Within DZIF, a separate research field is dedicated to this disease.

Jul 2019

Sci Rep

Generation and characterization of a stable cell line persistently replicating and secreting the human hepatitis delta virus

Autoren

Ni Y et al.

Jan 2025

Liver Int

Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg-IFNα-2a as Treatment for Chronic Hepatitis Delta

Autoren

Lampertico P et al.

Electron micrograph of a hepatitis C virus particle.

A major step for HCV research

The only natural host of the hepatitis C virus (HCV) is humans. Model organisms for laboratory studies, especially mice, cannot be infected which makes the search for a vaccine against HCV extremely

Jan 2025

JHEP Rep

Adapted hepatitis C virus clone infects innate immunity deficient mouse hepatocytes with minimal human HCV entry factors

Autoren

Sheldon JA et al.

DZIF Patient Advisory Board

Patients and their families play an increasingly important role in healthcare and clinical research. Their experiences and perspectives on living with a disease can provide researchers with valuable

Dec 2024

Science Advances

Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies

Autoren

Kumar Nagarathinam et al.

Vaccine research: new hope in the fight against hepatitis C

The development of an effective vaccine against the hepatitis C virus has been an enormous challenge for decades due to the high genetic diversity of the virus. The research team led by DZIF scientist

Aug 2024

Antiviral Res

Activating adaptive immunity by bispecific, T-cell engager antibodies bridging infected and immune-effector cells is a promising novel therapy for chronic hepatitis B

Autoren

Xie Z

Protzer U

Aug 2024

Sci Rep

Serological indication of chronic inflammatory demyelinating polyneuropathy as an extrahepatic manifestation of hepatitis E virus infection

Autoren

Pischke S et al.

Jul 2024

J Hepatol

Hepatitis B Virus DNA integration: Implications for diagnostics, therapy, and outcome

Autoren

Zoulim F et al.