Hybridoma technology | German Center for Infection Research

Short description

The hybridoma technology is a method for producing monoclonal antibodies. It allows customised monoclonal antibodies to be produced in large quantities.

Synonyms

Hybridom-Technik, Hybridomatechnik

Detailed description

B lymphocytes, which produce the desired antibodies, are fused with immortalised myeloma cells (cancer cells). This fusion enables the cultivation and multiplication of the desired antibodies: B cells only have a limited lifespan and myleoma cells are strongly deregulated cells that are not subject to programmed cell death. Only the hybridoma cells are able to secrete unrestricted monoclonal antibodies.

Bonn - Köln

Antibacterial Vaccines and Diagnostics Development (ACTIVATE)

The DZIF working group "Antibacterial Vaccines and Diagnostics Development" (ACTIVATE) led by Alexander Klimka develops active and passive vaccines against bacterial pathogens and antibody-based rapid tests to detect antibiotic-resistant bacteria. In 2017, the World Health Organization (WHO) ...