Latency | German Center for Infection Research

Short description

Latency refers to a viral state in which the virus is integrated in the DNA of its host cell and in which no viral proteins are produced.

Detailed description

Infections are difficult to detect in this phase. No new virus particles are produced. Drugs and the host are unable to eliminate the viruses. Different stimuli such as UV light or stress can cause reactivation of the viruses followed by the respective symptoms. Viruses with a latency phase are, for example, and herpes viruses.

Close up view of the injection of a vaccine through a syringe into the arm of a person wearing a mask.

New vector vaccine against COVID-19 provides long-term protection

The protective effect of established COVID-19 vaccines is initially very robust, but wanes relatively quickly. This limitation imposes a need for periodic booster shots, which drives vaccine

Mar 2024

J Virol

Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice

Autoren

Ouwendijk WJD et al.

Jun 2023

Curr Opin Virol

Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen: more than a key mediator of viral persistence

Autoren

Schulz TF

Freise A

Stein SC

Transmission electron microscopy image of spherical cytomegalovirus virions grown in tissue culture. The virions are digitally stained blue.

A virus lurking in the connective tissue

It was previously believed that herpesviruses use certain body cells to replicate and other body cells to remain dormant, that is to remain inactive for a longer period of time. This dogma is now

Apr 2017

PLoS Pathog

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency

Autoren

Mariggio G

Koch S

Apr 2017

Angew Chem Int Ed Engl

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence

Autoren

Weidner-Glunde M

Mariggio G

Schulz TF

May 2022

J Virol

DLK-Dependent Biphasic Reactivation of Herpes Simplex Virus Latency Established in the Absence of Antivirals

Autoren

Dochnal S et al.

Jun 2016

PLoS One

Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems

Autoren

Bialek JK et al.

Sep 2015

Cell Host Microbe

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

Autoren

Pache L et al.

Jul 2021

EMBO Mol Med

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

Autoren

Shytaj IL et al.