Mycobacterium tuberculosis complex refers to Mycobacterium species that cause tuberculosis.
Synonyms
MTC
MTBC
Detailed description
They are obligatory pathogenic, meaning they cause disease also in healthy humans. They mainly infect macrophages, the immune system’s scavenger cells. The Mycobacterium tuberculosis complex comprises the following species: M. tuberculosis, M. bovis, M. africanum, M. microti, M. canetti and M. pinnipedii as well as the vaccinal strain M. bovis BCG. They are differentiated from M. leprae and the non-tuberculous mycobacteria.
Professors Ivo Boneca (Institut Pasteur, Paris), Mark Brönstrup (Helmholtz Centre for Infection Research, Braunschweig, and German Center for Infection Research), and Christophe Zimmer (University of
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Different groups of TB bacteria exist worldwide with different regional distribution: some are generalists and can be found on many continents, while others are very limited in their spread. An
The antibiotic Bedaquiline (BDQ) was approved in 2014 specifically for the treatment of multidrug-resistant (MDR) tuberculosis (TB) and has since been an important component of successful MDR TB
