Pharmacokinetics | German Center for Infection Research

Short description

Pharmacokinetics deals with concentrations of a drug and its degradation products within the body.

Detailed description

The following processes can be investigated: if applicable, release of a drug from the pharmaceutical formulation, uptake into the blood circulation, distribution throughout the body, metabolism and excretion. Pharmacokinetics is especially important for the approval of new drugs.

University of Tübingen

PAFAP—Pseudomonas aeruginosa-focused anti-infectives pipeline

In the current WHO list of bacterial priority pathogens (WHO BPPL 2024), the World Health Organisation classifies carbapenem-resistant Pseudomonas aeruginosa bacteria as a high-priority pathogen, which means there is an urgent need for new anti-infectives to combat this problematic bacterium. To ...

Study on promising new antibiotic Darobactin reinforces its potential

Darobactin is a promising candidate for the development of new, resistance-breaking antibiotics, as it has an exceptional mechanism of action and a broad spectrum of activity. In a recent study, DZIF

Cryo-electron microscopic reconstruction of molecular structures: On the left, the vertical representation of the binding of a yellow-coloured antibody to the blue-coloured tip of the secretion system shown in grey. On the right, a top view of the binding structure, showing how the yellow antibody binds laterally to the blue tip of the secretion system, which is round in top view.

Neutralising antibodies that target resistant bacteria

Antibiotic-resistant bacteria pose a major challenge to healthcare systems worldwide. Due to numerous resistance mechanisms, infections with the pathogen Pseudomonas aeruginosa are particularly feared

Jun 2023

Trials