RNA interference | German Center for Infection Research

Short description

RNA interference is a natural mechanism by which genes in cells can be targeted for silencing.

Synonyms

RNA Silencing

RNAi

Detailed description

RNA interference is triggered by small, double-stranded RNA molecules called siRNA (small interfering RNA). RNA interference is thought to be, among other things, a protective mechanism of the cell against "non-cellular" RNA, for example viral RNA. RNAi is also increasingly used as a genetic engineering technique in laboratory experiments.

Prof Ulrich Kubitscheck, Jan-Samuel Puls, Dominik Brajtenbach and Dr Fabian Grein (from left to right), all in white lab coats, photographed as a group in the lab.

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The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses

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Two female researchers in white lab coats, one sitting at a lab bench and one standing behind her, discuss the results of a cell examination on a computer screen. Sitting next to them, another researcher is working on another piece of laboratory equipment.

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Right on target: The next class of efficient, safe, and specific RNAi triggers

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Becker J

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PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis B

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