Computer-based genome mining of natural compounds

The majority of successful antibiotics are derived from microorganisms and the potential of finding new agents in this group is yet to be exploited. Using genome sequencing, scientists have frequently discovered gene clusters with potential antibiotic activity. However, synthesis does not occur under laboratory conditions. Computer-based genome mining analysis, developed by Nadine Ziemert, a member of this research group, enables vast amounts of data to be combed through quickly and efficiently in the search for novel antibiotics with alternative mechanisms of action. Through the use of genetic methods, these bioinformatically-identified genes are activated directly in the laboratory which lays the foundation for the rapid discovery and investigation of new antibiotic molecules.