Medicinal chemistry of novel anti-infectives

Medicinal chemistry, also termed medical chemistry, researches chemical properties of new and old agents and develops innovative therapy options. Ralph Holl’s research group focuses on manufacturing and/or designing new inhibitors: small molecules that specifically target metabolic pathways in bacteria and consequently act as antibiotics. Meanwhile, a large number of 3D protein structures that play a role in the interactions between host and bacteria interactions exist, which enables small molecules to be adapted to target specific structures. Avoiding a development of resistance plays a major role. Ralph Holl and his team synthesise, characterise and test novel antibiotics that have previously unused mechanisms of action.