cccDNA | German Center for Infection Research

Short description

The cccDNA is a special, ring-shaped DNA structure that appears in the cell nucleus during the replication of some viruses and can persist there.

Synonyms

covalently closed circular DNA

Detailed description

The cccDNA occurs, for example, in hepatitis and represents the central reservoir that enables the viruses to survive in the liver and thus accounts for the chronic disease pattern. Scientists are developing therapies that can silence the cccDNA in the nucleus of infected cells.

May 2024

J Med Virol

Development of a single-domain antibody to target a G-quadruplex located on the hepatitis B virus covalently closed circular DNA genome

Autoren

Figueroa GB et al.

May 2023

Microbiol Spectr

SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA

Autoren

Hofmann S et al.

A cell culture plate with twelve wells is filled with a red liquid using a pipette.

New standards to quantify hepatitis B virus reservoirs in liver cells

Approximately 300 million people worldwide are chronically infected with the hepatitis B virus (HBV) and at high risk of developing liver cirrhosis or hepatocellular carcinoma. Consequently, there is

Jan 2023

Gut