Directly acting antivirals | German Center for Infection Research

Short description

Directly acting antivirals (DAA) are novel drugs for the treatment of C, which directly the hepatitis C virus.

Synonyms

DAA

Detailed description

DAAs directly attack the C virus () preventing its amplification. DAAs raise high hopes as previous treatments of HCV were relatively unspecific.

Jul 2024

JHEP Rep

Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients

Autoren

Dietz J et al.

Jan 2024

Pharmaceutics

Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against Onchocerca gutturosa in Gambia

Autoren

Gokool S et al.

Feb 2024

JHEP Rep

Real-world effectiveness of voxilaprevir/velpatasvir/sofosbuvir in patients following DAA failure

Autoren

Graf C et al.

Apr 2023

Hepatology

Therapeutic preparedness: DAA-resistant HCV variants in vitro and in vivo

Autoren

Dietz J

Lohmann V

Aug 2022

J Hepatol

Long-term persistence of HCV resistance-associated substitutions after DAA treatment failure

Autoren

Dietz J et al.

Mar 2022

mBio

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters

Autoren

Shytaj IL et al.

Oct 2016

Clin Gastroenterol Hepatol

HCV Resistance Profile Evolution in a GT1b, DAA-Naive Patient Before, On, and After Failing Triple DAA Therapy

Autoren

Knops E et al.

Oct 2014

PLoS One

Treatment of naïve patients with chronic hepatitis C genotypes 2 and 3 with pegylated interferon alpha and ribavirin in a real world setting: relevance for the new era of DAA

Autoren

Heidrich B et al.

May 2021

Scand J Gastroenterol

Evolution of liver stiffness and post-treatment surveillance by liver elastography for HCV patients in the DAA era

Autoren

Piecha F et al.

May 2020

PLoS One

Treatment and re-treatment results of HCV patients in the DAA era

Autoren

Piecha F et al.