Genome Mining | German Center for Infection Research

Short description

Genome mining refers to gaining information on an organism based on methods of genome analytics.

Detailed description

The genome mining approach is for example useful to find secondary metabolites of bacteria that might be used for drug development in a much more targeted manner. It allows predicting and isolating solely based on genetic information, without knowing their structure.

May 2023

Nucleic Acids Res

FunARTS, the Fungal bioActive compound Resistant Target Seeker, an exploration engine for target-directed genome mining in fungi

Autoren

Yılmaz TM et al.

Universität zu Lübeck

MiFactR—Microbiota- and treatment-derived determinants of antibiotic resistance

There are a number of factors responsible for the development of antibiotic resistance. So far, the interactions between pathogens and the complex microbial colonisation (microbiota) of the human body under the selection pressure of antibiotic treatment play a little studied and underestimated role ...

Targeted test for antibiotic resistance in clinical Enterobacter species

Bacteria of the genus Enterobacter are among the most dangerous bacteria associated with hospital infections worldwide. Some of their representatives are highly resistant to commonly used antibiotics

Dec 2017

ACS Chem biol

Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach

Autoren

Surup F et al.

Mar 2022

J Nat Prod

Genome-Mining-Guided Discovery and Characterization of the PKS-NRPS-Hybrid Polyoxyperuin Produced by a Marine-Derived Streptomycete

Autoren

Kresna IDM et al.

Visualisation of luminous strands of DNA as well as of a ring that depicts the combined analysis of many different bacterial genomes.

Only three percent of potential bacterial drug sources known

The emergence of antibiotic-resistant pathogens and the increasing difficulty in developing new drugs has contributed to global challenges in combating infectious diseases. An extensive bioinformatics

May 2015

Nucleic Acids Res