A natural compound is a substance produced by bacteria, animals, fungi or plants that fulfills a biological function.
Detailed description
A large part of the currently used active substances is derived from natural compounds, which have been optimized by scientists for their application in humans. They fulfill a special function in the producing organisms like for example the defense against predators. Using high-throughput methods, scientists screen different organisms and use the identified substances to compile substance libraries, which can then be searched for specific functions.
Antibacterial drugs are important for treating infections. However, increasing bacterial resistance to current drugs—making them ineffective or only partially effective—means that new drugs are
Antimicrobial resistance (AMR) is one of the most urgent challenges facing global health and development. Described as a “creeping pandemic” by the G7 forum of leading economic nations, AMR occurs
Professors Ivo Boneca (Institut Pasteur, Paris), Mark Brönstrup (Helmholtz Centre for Infection Research, Braunschweig, and German Center for Infection Research), and Christophe Zimmer (University of
Most antibiotics used in human medicine originate from natural products derived from bacteria and other microbes. Novel microorganisms are therefore a promising source of new active compounds—also for
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Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers at the University Hospital Bonn (UKB), the University of Bonn and
Tuberculosis and malaria are among the deadliest infectious diseases worldwide and are increasingly spreading, not least due to climate change. In both cases, antimicrobial resistance renders
Today, UNITE4TB, an international public-private partnership striving to fast-track the development of innovative tuberculosis (TB) treatments, announced the start of its phase-IIb/c-clinical trial
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More and more bacterial pathogens are developing resistance. There is an increasing risk that current drugs will no longer be effective against infectious diseases. Scientists around the world are
