Humanized mice | German Center for Infection Research

Short description

Humanized mice carry components of the human .

Detailed description

They are supposed to improve the transferability of data from mouse models to humans. The mouse strains used do not possess an of their own but only human genes, cells, tissues or organs that were artificially transferred to them. They are deployed to test therapeutics, for instance.

Jul 2020

PLoS Pathog

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

Autoren

Theobald SJ et al.

Jun 2020

EMBO Mol Med

Innovations, challenges, and minimal information for standardization of humanized mice

Autoren

Stripecke R et al.

Feb 2020

Vaccines (Basel)

Modeling Human Cytomegalovirus in Humanized Mice for Vaccine Testing

Autoren

Koenig J

Theobald SJ

Stripecke R

Nov 2019

JCI Insight

Comparative pathogenesis of Ebola virus and Reston virus infection in humanized mice

Autoren

Escudero-Pérez B et al.

Bonn - Köln

Humanised Mouse Core Cologne

Humanised mice carrying human genes or cells, for example, are a crucial model for disease research and drug development. Generating them and keeping them in optimal conditions requires a lot of know-how and experience. Therefore, a professional central unit with humanised mice (Humanized Mouse Core ...

Dec 2018

Am J Pathol

Spatio-Temporally Skewed Activation of PD-1(+) T Cells after Epstein Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice

Autoren

Danisch S et al.