Mouse model | German Center for Infection Research

Short description

A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.

Detailed description

Mice share mammalian features with humans and suffer from many of the same diseases. That makes them particularly useful as animal models.

Helmholtz Centre for Infection Research

Development of corramycin as an antibiotic against Gram-negative bacteria

Gram-negative bacteria are naturally insensitive to many antibiotics due to their additional outer membrane. In addition, the bacteria have acquired resistance to clinically used antibiotics in recent decades, resulting in multidrug-resistant bacteria. Novel classes of antibiotics are needed to ...

The image shows a highly magnified electron micrograph of several oval, slightly rough Escherichia coli bacterial cells. The colour of the image is a reddish tone. The background is dark and highlights the bacteria.

Chemical trick activates antibiotic directly at the pathogen

Colistin is a last-resort antibiotic that is usually only used for severe infections with resistant bacteria. This is due to its severe kidney-damaging side effects, which occur in around 30 percent

Close up view of the injection of a vaccine through a syringe into the arm of a person wearing a mask.

New vector vaccine against COVID-19 provides long-term protection

The protective effect of established COVID-19 vaccines is initially very robust, but wanes relatively quickly. This limitation imposes a need for periodic booster shots, which drives vaccine

Four schematically depicted people in purple, blue, yellow and pink outerwear against a green background with a grey-shaded group of people.

World Hepatitis Day: a call for increased international commitment in the fight against hepatitis

The motto of this year's World Hepatitis Day, proclaimed annually on 28 July by the World Health Organisation (WHO), is “It's time to act". Hundreds of millions of people worldwide are affected by

Jan 2024

Int J Parasitol

Development of adult Dirofilaria immitis worms in the Rag2/Il-2rγ(-/-) mouse model

Autoren

Risch F et al.

Jan 2024

Infect Immun

Contribution of bacterial and host factors to pathogen "blooming" in a gnotobiotic mouse model for Salmonella enterica serovar Typhimurium-induced enterocolitis

Autoren

Beutler M et al.

Schematic representation of a liver (in brown-orange) surrounded by round virus particles and blood cells (in white-gray).

A promising investigational therapeutic monoclonal antibody to treat chronic hepatitis B and D infections

Affecting hundreds of millions of people, chronic hepatitis B is a widespread global health problem for which there is as yet no cure. In a preclinical study involving the German Center for Infection

Measles-based vector vaccine protects mice against influenza A (H7N9) virus

Researchers of the German Center for Infection Research (DZIF) at the Paul-Ehrlich-Institut (PEI) and Philipps-Universität Marburg used the "recombinant measles virus" vaccine platform to test vaccine

Mar 2023

Viruses

Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research

Autoren

Kitsera M

Brunetti JE

Rodríguez E

Illustration of a mouse surrounded by: Bacteria-containing capsules; red and green agar plates with bacterial colonies smeared out and test strips and platelets; DNA sequence comparison behind; and the words "Antibiotics", "Microbiome", and "Evolution".

How the gut microbiome responds to antibiotics

Antibiotics affect the composition and dynamics of the gut microbiome. Treatment with antibiotics not only leads to a loss of biodiversity of microorganisms, but also often favours the selection of