In drug development, preclinical tests are carried out to investigate the behavior of novel agents in cell culture or animal models.
Detailed description
The aim of preclinical tests is to identify substances showing a therapeutic effect. Cell cultures and animal models are used to investigate whether these substances are toxic, damage the genetic material or induce malformations. This phase lasts ten years on average. Only few of the substances examined are suitable for further testing in humans and the subsequent clinical phase.
Developing a new medication usually takes more than ten years. Out of the several thousand substances investigated in basic and pre-clinical research, only one or two candidates are approved by
Primary human liver cells are required in order to investigate infections of the liver and to conduct preclinical tests of new agents. Isolating them from patient samples is a technologically challenging process requiring the highest levels of skill. This skill is available at the “Primary Human ...
The first antibiotic against tuberculosis that has been developed in Germany is now ready for clinical testing. BTZ043, as the newly developed drug substance is called, is also effective against
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