Antibiotic resistance is a bacterial defense mechanism against antibiotics. It can rapidly spread from one bacterium to another. This makes antibiotics increasingly ineffective.
Detailed description
The level of resistances against antibiotics is rising. This is a great challenge for physicians and scientists. Scientists within the DZIF research field “Healthcare-associated and Antibiotic-resistant bacterial Infections” aim to develop new strategies against the development and spread of resistance.
Infections with the bacterium Clostridioides difficile (C. difficile for short) frequently recur due to permanent stages remaining in the intestine. A drug that also effectively combats the permanent
The pathogenHelicobacter pylori, which is responsible for highly prevalent diseases such as gastric ulcers or cancer, has a weak spot that could be used to produce new drugs. This was discovered by a
In many infections, even proper antibiotic treatment does not lead to the expected therapeutic success. In the case of treatment with antibiotics, the doctor usually first decides which antibiotic to prescribe based on the type of infection. If resistance to the antibiotic already prescribed is ...
The antibiotic Bedaquiline (BDQ) was approved in 2014 specifically for the treatment of multidrug-resistant (MDR) tuberculosis (TB) and has since been an important component of successful MDR TB
We still do not understand exactly how antibiotics kill bacteria. However, this understanding is necessary if we want to develop new antibiotics. And that is precisely what is urgently needed, because
Prof. Ernst's working group operates at the interface of molecular microbiology, genomics, epidemiology and chemical biology to identify, investigate, and target unrecognised pathways in persistent and multidrug-resistant infections. To this end, the group conducts mechanistic investigations ...
According to the World Health Organisation (WHO), approximately 1.5 million people die each year from tuberculosis (TB), a disease of the lungs caused by Mycobacterium tuberculosis. People with a
The COVID-19 pandemic has dramatically demonstrated that the development of effective agents against viral pathogens is of great importance for global health. Although effective vaccines are available
A long-term study by the Research Center Borstel, Leibniz Lung Center was able to show that the therapeutic success of patients with multidrug-resistant tuberculosis is much higher than previously