CD4 T lymphocyte | German Center for Infection Research

Short description

CD4 T lymphocytes form a subgroup of T lymphocytes that is responsible for cell-mediated immune responses.

Synonyms

T helper cell

CD4 cells

Detailed description

T lymphocytes carrying the surface CD4 are called T helper cells. After activation, they release substances that are either involved in cell-mediated immunity or that stimulate B cell immune responses. infects mainly this T subgroup.

Fluorescence micrograph of blue-stained cells on a black background. In the left half of the image, green-stained Lec A-proteins bind to the cells. In the right half of the image, only blue-stained cells are visible.

Sugar-based inhibitors disarm the pathogen Pseudomonas aeruginosa

The hospital germ Pseudomonas aeruginosa forms biofilms, a kind of mucus layer, to protect itself from attack by the immune system or antibiotics. To form this sticky layer, as well as to successfully

Nov 2022

Angew Chem Int Ed Engl

Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors

Autoren

Zahorska E et al.

Sep 2022

Pathogens

Tuberculosis Treatment Response Monitoring by the Phenotypic Characterization of MTB-Specific CD4+ T-Cells in Relation to HIV Infection Status

Autoren

Sitoe N et al.

Sep 2022

Front Immunol

Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI

Autoren

Ramirez N et al.

Oct 2022

Genes (Basel)

Allele-Specific Disruption of a Common STAT3 Autosomal Dominant Allele Is Not Sufficient to Restore Downstream Signaling in Patient-Derived T Cells

Autoren

König S et al.

Jul 2022

JHEP Rep

Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells

Autoren

Tu T et al.

Oct 2022

Signal Transduct Target Ther

Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant

Autoren

Odak I

Förster R

Bošnjak B

Oct 2022

PLoS Negl Trop Dis

Diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction

Autoren

Gallo G et al.

Jan 2023

J Hepatol

Activation of CD4 T cells during prime immunisation determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models

Autoren

Su J et al.

Unraveling key determinant of successful therapeutic vaccination against chronic hepatitis B

Hepatitis B virus (HBV) infections remain a major global health problem – according to the World Health Organization (WHO) there are around 300 million HBV carriers worldwide. Current treatments