Clinical phase

Short description

The clinical phase is a phase in drug development, in which the substance is tested in humans.

Detailed description

It follows the preclinical phase, in which, for example, toxicity of the potential drug is investigated. The clinical part is divided into three phases, which look at different aspects. At the beginning, tolerance is tested in healthy people in a “First-in-human” study. Next, the effect in patients is investigated and, finally, effectiveness and harmlessness need to be confirmed.

Study with optimized vector vaccine MVA-SARS-2-S resumed

The clinical review of the MVA-SARS-2-S vector vaccine against COVID-19 will continue with a new version. The DZIF (German Center for Infection Research) scientists temporarily suspended the study

A tapeworm drug against SARS-CoV-2?

Researchers from the German Center for Infection Research (DZIF) at Charité – Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism

MERS coronavirus: Vaccine development is going into the next round

In addition to the SARS coronavirus-2 that is currently prevalent worldwide, scientists continue to keep an eye on the related MERS coronavirus, as it, too, could potentially become a supra-regional

The clock is ticking! Three people dying of tuberculosis every minute

The clock is ticking: The motto of this year's World Tuberculosis Day makes clear that tuberculosis still remains one of the world's deadliest infections. In particular, people in poorer countries are

Hannover Medical School

Clinical cohorts for HIV remission

The project “Clinical cohorts for HIV remission” will continue and expand ongoing research around the treatment of primary HIV infection (TopHIV) Cohort of patients with acute HIV infection. Beyond studies about their immune responses and reservoir formation, selected TopHIV individuals will be ...

Bonn - Köln

Translational Microbiology

Prof. Marc Hübner aims to identify new drug candidates against parasitic threadworms, so-called filariae, and developing them further for human use. To this end, new in vitro and in vivo models are being developed and identified candidates are being tested in clinical trials in humans. With ...