Multidrug resistance | German Center for Infection Research

Short description

Multidrug resistance means that bacteria or viruses are insensitive towards various antibiotics or antivirals, respectively.

Synonyms

Multiple drug resistance

Detailed description

There is a general increase of resistances against antibiotics. Infections with multidrug-resistant pathogens pose a serious problem as their treatment with antibiotics is difficult or not possible any more.

Cryo-electron microscopic reconstruction of molecular structures: On the left, the vertical representation of the binding of a yellow-coloured antibody to the blue-coloured tip of the secretion system shown in grey. On the right, a top view of the binding structure, showing how the yellow antibody binds laterally to the blue tip of the secretion system, which is round in top view.

Neutralising antibodies that target resistant bacteria

Antibiotic-resistant bacteria pose a major challenge to healthcare systems worldwide. Due to numerous resistance mechanisms, infections with the pathogen Pseudomonas aeruginosa are particularly feared

Portrait of Dr. Janko Sattler. Mr Sattler is wearing a dark suit and tie.

Research award for DZIF Scientist Janko Sattler

DZIF scientist Dr Janko Sattler, a medical specialist at the Institute for Medical Microbiology, Immunology and Hygiene at the University Hospital Cologne, was awarded the bioMérieux Diagnostics Prize

The photo shows a group of four researchers (three women and one man) in white lab coats in a laboratory.

Researchers decode new antibiotic agent

More and more bacterial pathogens are developing resistance. There is an increasing risk that current drugs will no longer be effective against infectious diseases. Scientists around the world are

Jan 2023

Antibiotics

Klebsiella pneumonia in Sudan: Multidrug Resistance, Polyclonal Dissemination, and Virulence

Autoren

Osman EA et al.

Schematic representation of two agar plates, each with a paper strip. On the left plate, an inhibition zone can be seen around the paper strip.

Targeting resistance to a crucial reserve antibiotic

Colistin is a last-line reserve antibiotic for the treatment of infections caused by extremely multidrug-resistant (XDR) Gram-negative bacteria. The recent emergence and global spread of the mobile

Launch of the EU-funded project eWHORM – enabling the WHO Road Map: Eliminate worm infections in Sub-Saharan Africa

African and European partners join forces to enable the World Health Organisation’s (WHO) “Road Map for Neglected Tropical Diseases” (NTDs) and reduce the burden of disease associated with worm

Schematic representation in 3D of the transcription factor Rv0678. Some spiral amino acid chains are highlighted in purple or gold.

Identifying and combating new antibiotic resistance in tuberculosis early on

The antibiotic Bedaquiline (BDQ) was approved in 2014 specifically for the treatment of multidrug-resistant (MDR) tuberculosis (TB) and has since been an important component of successful MDR TB

Bonn - Köln

Host pathogen interactions in antibiotic-resistant and persistent infections

Prof. Ernst's working group operates at the interface of molecular microbiology, genomics, epidemiology and chemical biology to identify, investigate, and target unrecognized pathways in persistent and multidrug-resistant infections. To this end, the group conducts mechanistic investigations ...

Fünf gezeichnete Personen (Ärztinnen, Wissenschaftler und Patient:innen) auf rotem Hintergrund, mit hoffnungsvollen Gesichtsausdrücken

World Tuberculosis Day 2023: Yes! We can end TB!

According to the World Health Organisation (WHO), approximately 1.5 million people die each year from tuberculosis (TB), a disease of the lungs caused by Mycobacterium tuberculosis. People with a

Long-term outcomes of multidrug-resistant tuberculosis better than expected

A long-term study by the Research Center Borstel, Leibniz Lung Center was able to show that the therapeutic success of patients with multidrug-resistant tuberculosis is much higher than previously