Persistence | German Center for Infection Research

Short description

In infection biology, persistence refers to a being able to survive in a patient’s body.

Detailed description

persistence means that a pathogen continuously replicates like during a chronic infection or that it survives in a silent form in a refuge space within the body. Certain conditions can reactivate the silent form and cause again disease.

New combination therapy offers chance of healing hepatitis B

Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as

Ludwig-Maximilians-Universität München

Reduction and elimination of HIV reservoirs

The development of potent antiretroviral treatment (ART) strategies has significantly changed the face of the HIV/AIDS pandemic from a lethal disease to a chronic livable condition for infected individuals with access to care. However, in spite of ground-breaking advances in anti-HIV treatment, cure ...

First drug for hepatitis D has been approved by European Commission

Joint press release from Heidelberg University and the German Center for Infection Research (DZIF)

What started off as basic research 25 years ago has now led to a successfully approved drug: The

Helicobacter pylori: Signs of selection in the stomach

Helicobacter pylori, a globally distributed gastric bacterium, is genetically highly adaptable. The DZIF team of Professor Sebastian Suerbaum at LMU has now characterized its population structure in

Apr 2019

Hepatology

Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

Autoren

Jensen SB et al.

Dec 2017

Hum Gene Ther

S/MAR Element Facilitates Episomal Long-Term Persistence of Adeno-Associated Virus Vector Genomes in Proliferating Cells

Autoren

Hagedorn C et al.

Aug 2018

J Clin Microbiol

Mycobacterium bovis Persistence in Two Different Captive Wild Animal Populations in Germany: a Longitudinal Molecular Epidemiological Study Revealing Pathogen Transmission by Whole-Genome Sequencing

Autoren

Kohl TA et al.

Hepatitis B: Cure is the goal

Worldwide, approximately 260 million people suffer from chronic hepatitis B which is currently incurable. However, there is now a shimmer of hope on the horizon as scientists at the DZIF have

Dr Saskia C. Stein, Prof Christine Josenhans and Eugenia Faber (left to right)

New approach to gastritis treatment

Scientists from the Hannover Medical School (MHH) have elucidated how Helicobacter pylori causes gastritis. Chronic infections with the globally ubiquitous pathogen can also lead to gastric ulcers and

Apr 2018

Lancet Infect Dis

Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study

Autoren

Huttner A et al.