Sepsis | German Center for Infection Research

Short description

Sepsis develops as a result of an infection when the immune response harms the body’s own tissues and organs. Without intensive care, sepsis is often fatal.

Synonyms

Septicemia

Blood poisoning

Detailed description

Originating from a local inflammation such as a wound or pneumonia, pathogens or their toxins spread in the body and activate the entire . A key role plays lipopolysaccharide, which is found in the membrane of bacteria. The over-activated immune system floods the body with messenger substances. Possible consequences are a multitude of inflammatory reactions, shock, multi-organ failure and death. The immediate administration of antibiotics as well as the maintenance of the blood circulation is pivotal. Sepsis is the third most common illness-related cause of death in Germany.

Scientists sound the alarm over lack of antibiotics

According to the WHO, antimicrobial resistance (AMR) is one of the ten greatest threats to global health. In the EU alone, around 35,000 people die every year from antibiotic-resistant infections. The

Several mustard-coloured, spherical bacteria in the middle of much smaller blue-coloured blood cells.

Phage lysin compound HY-133: Start of clinical phase I “first-in-human” study to eliminate Staphylococcus aureus in the nasal microbiome

The novel active agent HY-133, which was developed by HYpharm and prepared for clinical trials in collaboration with the German Center for Infection Research (DZIF) and universities in Tübingen

DZIF mourns the death of Professor Tobias Welte

Professor Tobias Welte, a scientist at the German Center for Lung Research (DZL) and the German Center for Infection Research (DZIF), died on Sunday after a short, serious illness. We are deeply

New treatment options for bloodstream infections

Study shows efficacy and safety of oral antibiotic therapy in the form of pills for Staphylococcus aureus bloodstream infections. Currently, infusions are the standard treatment / published in ‘The

Call for action by the German Network against Antimicrobial Resistance (DNAMR)

"We are heading towards a crisis with our eyes wide open. Soon we will lack the antibiotics we need to perform vital operations," says Dr Timo Jäger, Managing Director of the German Center for

Aug 2023

J Clin Med

New Perianal Sepsis Risk Score Predicts Outcome of Elderly Patients with Perianal Abscesses

Autoren

Reichert M et al.

Mar 2023

Acta Paediatr

European study confirms the combination of fever and petechial rash as an important warning sign for childhood sepsis and meningitis

Autoren

Kohlmaier B et al.

DNAMR

The "Deutsches Netzwerk gegen Antimikrobielle Resistenzen" (DNAMR; German Network against Antimicrobial Resistance), launched…

Nov 2022

Infection

Clinical features, treatment outcomes and mortality risk of tuberculosis sepsis in HIV-negative patients: a systematic review and meta-analysis of case reports

Autoren

Adegbite BR et al.

University of Cologne

Development and integration of advanced diagnostics into routine clinical care (INTEGRATE)

By applying innovative diagnostic methods such as rapid point-of-care tests, multi-omics technologies as well as novel predictive models, clinical management and thus most likely treatment outcomes can be improved. In addition to the high information content of these new methods, the prompt ...