Hepatitis

A detailed understanding of cellular immune responses in acute and chronic hepatitis is essential for the development of new drugs against hepatitis B and D infections. This means that standardised immunomonitoring under the necessary security conditions of risk level 3 is required, where immune cells can be sorted and genotypically [...]

A microscopy unit was established at the Heidelberg Partner Site for research groups from the research field “Hepatitis” and other research fields including “Emerging Infections”, “Malaria and Neglected Tropical Diseases” and “HIV” in particular. The working group microscopy of hepatitis viruses enables research groups to conduct their analyses and investigate [...]

Professor Andreas Pichlmair and his team study the interactions between viruses and the human immune system. They aim to determine how the immune system reacts to an external attack and how this affects the pathogen. Human cells have developed a technique to combat viruses. However, viruses themselves have so-called immunomodulators [...]

Besides analysing replication mechanisms of hepatitis B (HBV) and D (HDV) viruses, the focus of Professor Stephan Urban and his team is to develop new drugs against these pathogens. With Myrcludex B, which blocks the entry of viruses into the liver cell, a substance has already been taken from basic [...]

Professor Markus Cornberg and his translational research group provide the necessary link between hospitals, the HepNet Study House trial platform and scientific activities at the DZIF. At the Hannover Medical School, Cornberg is clinically responsible for the Hepatitis Outpatient Clinic and for the Infectious Disease Ward in the Department of [...]

Primary human liver cells are required in order to investigate infections of the liver and to conduct preclinical tests of new agents. Isolating them from patient samples is a technologically challenging process requiring the highest levels of skill. This skill is available at the “Primary Human Liver Cells” central facility [...]

The HepNet Study-House connects individual trial centres in the hepatitis research field, creating a central platform for conducting clinical trials (investigator initiated trials). In addition, it establishes patient cohorts for viral hepatitis research. On the one hand, the Study-House is a point of contact for scientists and collaboration partners who [...]